Research Labs

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45 Faculty Members found
Memorial Hospital Research Laboratories
The Antonescu Lab
Cristina R. Antonescu, MD
My sarcoma research laboratory is dedicated to the detection and molecular characterization of diagnostic and prognostic markers in soft tissue sarcomas. Our current research is focused on 4 areas: (1) KIT oncogenic signaling in the pathogenesis of GIST and mechanisms of drug resistance to targeted kinase inhibitor therapies; (2) oncogenic signaling in angiosarcoma, with the characterization of KDR (VEGFR2) activating mutations in breast angiosarcoma and MYC/FLT4 gene amplifications in radiation-associated angiosarcoma; (3) fusion gene discovery and fusion transcript characterization in diagnosis and prognosis of soft tissue tumors; and (4) establishing genetically engineered sarcoma models using CRISPR-cas9 methodology for investigating the step-wise pathogenesis of translocation-associated sarcomas and generate faithful preclinical models for in vitro drug testing.
Cancer Biology & Genetics Program
Robert Benezra Lab Group
Robert Benezra, PhD
Cancer biologist Robert Benezra studies the molecular mechanisms of tumor growth and metastatic progression using mouse models. In addition, he studies the spindle assembly checkpoint which ensures proper chromosome segregation and is often deregulated in cancer.
Human Oncology & Pathogenesis Program
The Chen Lab
Yu Chen, MD, PhD
Physician-scientist Yu Chen studies the role of transcription factors that are critical for prostate cancer development.
Memorial Hospital Research Laboratories
Aimee Crago, MD, PhD
Physician-scientist Aimee Crago studies mechanisms by which common genomic events drive initiation and progression of soft tissue tumors.
Human Oncology & Pathogenesis Program
The James Fagin Lab
James A. Fagin, MD
Physician-scientist James Fagin focuses on the pathogenesis of thyroid cancer and the role of oncogenic kinases.
Molecular Pharmacology Program
The Karuna Ganesh Lab
Karuna Ganesh, MD, PhD
Physician-scientist Karuna Ganesh studies stem cell plasticity in metastasis, therapy resistance and tissue regeneration.
Molecular Pharmacology Program
The Jan Grimm Lab
Jan Grimm, MD, PhD
Radiologist and Nuclear Medicine physician Jan Grimm develops novel approaches for improved diagnosis, monitoring and therapy of prostate and other cancers.
Cell Biology Program
Kristian Helin Lab
Kristian Helin, PhD
Cancer biologist Kristian Helin studies how genetic and epigenetic mechanisms affect transcription and cell-fate decisions, and how their deregulation contributes to cancer.
Developmental Biology Program
The Danwei Huangfu Lab
Danwei Huangfu, PhD
The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.
Human Oncology & Pathogenesis Program
The Christine Iacobuzio-Donahue Lab
Christine A. Iacobuzio-Donahue, MD, PhD
Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.